Clinical Factors Evaluated When Choosing Treatment in Late-Line RRMM

Author(s):

Panelists discuss how treatment selection for late-line relapsed/refractory multiple myeloma (RRMM) balances multiple factors including patient fitness, prior therapy exposure, disease aggressiveness, side effect profiles, logistical considerations (with CAR-T requiring hospitalization while bispecifics can often be administered outpatient), financial accessibility and unique toxicity considerations (such as GPRC5D-targeting therapies affecting the skin and nails versus B-cell maturation antigen [BCMA]–targeting approaches), ultimately requiring a personalized approach weighing effectiveness against practical constraints on a patient-by-patient basis.

How do you decide between different treatment approaches, such as bispecific antibodies (BCMA/GPRC5D), CAR T-cell therapy or other targeted treatments?
What are the differences in effectiveness, side effects and accessibility between these therapies?

Clinical Factors Evaluated When Choosing Treatment in Late-Line RRMM

EP: 1.What is Late-Line RRMM and How is it Determined?

EP: 2.Challenges in Managing Late-Line RRMM

EP: 3.Linda’s Treatment History and Challenges in Coping With Multiple Relapses

EP: 4.Current Treatment Landscape for Late-Line RRMM

EP: 5.Clinical Factors Evaluated When Choosing Treatment in Late-Line RRMM

EP: 6.Patient’s Experience in Shared Decision Making in RRMM

EP: 7.Practical Considerations for Therapies Considered by the Patient and Caregivers in RRMM

EP: 8.Managing Treatment Logistics: Navigating Travel, Lodging and Caregiver Support

EP: 9.Recent Updates in Bispecifics and Their Use in Clinical Practice

EP: 10.Recent Updates in CAR-T Cell Therapy and Their Impact in Clinical Practice in RRMM

EP: 11.Balancing Benefits and Risks: Patients’ Experiences With Newer Therapies and Side Effects in Late-Line RRMM

EP: 12.Balancing Efficacy and Quality of Life in Late-Line RRMM

EP: 13.Aligning Treatment Goals: Key Considerations for Patients and Caregivers in Late-Line RRMM

EP: 14.Lifestyle Modifications That Have Been Helpful in RRMM

EP: 15.Addressing the Most Common Concerns Patients and Caregivers Have in Late-Line RRMM

EP: 16.Effective Communication Strategies: Sharing Concerns With Your Medical Team in Late-Line RRMM

EP: 17.Guidance for Caregivers: Supporting a Loved One Through Late-Line RRMM

EP: 18.Navigating RRMM: Helpful Resources and Advice for Patients Facing Disease Progression