Web Exclusive: Clinical Trials for CUP

A listing of clinical trials for patients with cancers of unknown primary are listed below.

Therapy: Treatment based on molecular profiling assay — paclitaxel, carboplatin, bevacizumab, erlotinib

Cancer: Carcinoma of Unknown Primary

Phase: II

Sponsor/Manufacturer: Sarah Cannon Research Institute/Genentech

Contact information: John D. Hainsworth, MD, 615-329-7274; jhainsworth@tnonc.com

Avastin (bevacizumab)

Therapy: Cancer: Neuroendocrine Carcinoma

Phase: III

Sponsor/Manufacturer: Southwest Oncology Group, National Cancer Institute

Contact information: James Yao, MD, 713-792-2828; jyao@mdanderson.org or 800-392-1611

Therapy: Taxotere (docetaxel), 5-FU (5-fluorouracil), Platinol (cisplatin)

Cancer: Squamous Cell or Undifferentiated Carcinoma

Phase: II

Sponsor/Manufacturer: M.D. Anderson Cancer Center/Sanofi-Aventis

Contact information: Ehab Y. Hanna, MD, 713-745-2672; eyhanna@mdanderson.org

Therapy: Xeloda (capecitabine)

Cancer: Solid Tumors and Adenocarcinoma of Unknown Primary

Phase: I/II

Sponsor/Manufacturer: Ohio State University Comprehensive Cancer Center

Contact information: OSU Cancer Clinical Trial Matching Service — 866-627-7616; osu@emergingmed.com

Therapy: Vectibix (panitumumab)

Cancer: Squamous Cell Carcinoma of the Head and Neck; Undifferentiated Carcinoma; Adenosquamous Cell Carcinoma

Phase: I

Sponsor/Manufacturer: Dana-Farber Cancer Institute; Brigham and Women’s Hospital; Massachusetts General Hospital/Amgen

Contact information: Lori J. Wirth, MD, 617-632-3090; lwirth@partners.org

Therapy: Nexavar (sorafenib)

Cancer: Advanced Solid Tumors

Phase: II

Sponsor/Manufacturer: University of California Davis

Contact information: UC Davis Clinical Trials Office — 916-734-3089 or Primo N. Lara, MD, 916-734-3772; primo.lara@ucdmc.ucdavis.edu

Therapy: Stereotactic Body Radiotherapy

Cancer: Spinal Neoplasms

Phase: I/II

Sponsor/Manufacturer: M.D. Anderson Cancer Center

Eric L. Chang, MD, 713-563-2300; echang@mdanderson.org

Contact information:

Investigators in clinical trials may be individual physicians, researchers at institutions, or pharmaceutical company representatives. The contact information given here was provided by those running these trials and was accurate at the time of publication. If you get a voice mail, leave the pertinent information. For additional trials, go to www.curetoday.com/trialcheck.