Early Data Suggest Promise for Immunotherapies in Lymphomas
October 13th 2015Questions persist regarding mechanisms of PD-L1 overexpression in lymphoid malignancies, patient selection, biomarkers to guide therapy and predict response, and identification of agents to use in combination with PD-1/PD-L1 inhibitors.
Molecular Subtype Proves to Be Prognostic Factor in Newly Diagnosed Gliomas
September 16th 2015This reanalysis confirmed that there is no difference for a radiotherapy-first versus a chemotherapy-first strategy in this setting, but there is a major difference in long-term outcomes for molecular stratification independent of treatment.
IDH Mutation Status May Guide Therapy in Patients With High-Risk Low-Grade Glioma
July 27th 2015An analysis of three interrelated biomarkers in high-risk low-grade glioma (LGG) has identified distinct risk groups by isocitrate dehydrogenase (IDH) mutation status and suggested appropriate treatment strategies.